Tuesday, July 25, 2017

Hope for a Heart Disease Vaccine


I wonder how much this would cost? And the follow up booster? Once you got the original vaccine at a give-away price would the booster price sky rocket? Hmmmm. Am I sounding cynical? Wouldn't it be nice if we could all eat well enough to make this unnecessary? But I know how hard that is, don't I?

A vaccine against heart ­disease has worked successfully in mice, raising the possibility that scientists will develop a breakthrough technique that could save millions of lives. Researchers in Europe tested the experimental vaccine on mice that were fed an unhealthy, high-fat Western diet, leaving them with high cholesterol and atherosclerosis, fatty buildup in the arteries that increases the risk of heart attack and stroke. The vaccine effectively lowered the total blood cholesterol level of the mice by 53 percent, The Guardian (U.K.) reports. It also reduced arterial damage linked to atherosclerosis by 64 percent and led to a 28 percent drop in markers of blood vessel inflammation. The vaccine works by triggering the production of antibodies that block an enzyme called PCSK9, which prevents the body from clearing LDL, or “bad” cholesterol from the blood. The antibodies produced by the vaccine remained at high levels throughout the entire 18-week study, suggesting the shot has long-term benefits, unlike daily cholesterol-lowering statin drugs, which can cause muscle pain, confusion, digestive issues, and other side effects. The vaccine is currently being tested on 72 people, with results of the Phase I clinical trial expected by the end of the year. “If these findings translate successfully into humans,” says Gunther Staffler, one of the vaccine’s developers, “we could develop a long-lasting therapy that, after the first vaccination, just needs an annual booster.”

Taken from the July 7, 2017 print edition of The Week Magazine.

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